Hyper-V: Anti-Virus Exclusions for Hyper-V Hosts

If you choose to run programs in the management operating system, you should also run your antivirus solution there and add the following to the antivirus exclusions to avoid negative performance impacts to all Virtual Machines running on that host:

• All folders containing VHD, VHDX, AVHD, AVHDX, VSV and ISO files
• Default virtual machine configuration directory, if used  C:\ProgramData\Microsoft\Windows\Hyper-V
• Default snapshot files directory, if used  %systemdrive%\ProgramData\Microsoft\Windows\Hyper-V\Snapshots
• Custom virtual machine configuration directories, if applicable
• Virtual machine virtual hard disk files directory. By default, it is C:\Users\Public\Documents\Hyper-V\Virtual Hard Disks. 
• Custom virtual hard disk drive directories
• Snapshot files directory. By default, it is %systemdrive%\ProgramData\Microsoft\Windows\Hyper-V\Snapshots. 
• Vmms.exe (Note: May need to be configured as process exclusions within the antivirus software)
• Vmwp.exe (Note: May need to be configured as process exclusions within the antivirus software)
• Additionally, when you use Cluster Shared Volumes, exclude the CSV path C:\ClusterStorage and all its subdirectories.